calcitonin family peptides

calcitonin family peptides
(= ADM; CGRP1; CGRP2; amylin; calcitonin)
Family of small (32-51 residue) highly homologous peptides that act through seven-transmembrane G-protein-coupled receptors. Adrenomedullin (ADM; 51 residues) is a potent vasodilator and has receptors on astrocytes; amylin (37 residues) is thought to regulate gastric emptying and carbohydrate metabolism; calcitonin (32 residues) is involved in control of bone metabolism; calcitonin-gene-related peptides 1 and 2 (37 residues) regulate neuromuscular junctions, antigen presentation, vascular tone and sensory neurotransmission. Receptors are themselves regulated by RAMPs.

Dictionary of molecular biology. 2004.

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  • calcitonin gene related peptide — (= CGRP) Neuropeptide of 37 amino acids with structural homology to salmon calcitonin. Co localizes with substance P in neurons. Intracerebral administration of CGRP leads to a rise in noradrenergic sympathetic outflow, a rise in blood pressure,… …   Dictionary of molecular biology

  • Calcitonin — is a 32 amino acid linear polypeptide hormone that is produced in humans primarily by the parafollicular cells (also known as C cells) of the thyroid, and in many other animals in the ultimobranchial body.[1] It acts to reduce blood calcium… …   Wikipedia

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  • Secretin receptor family — Pfam box Symbol = 7tm 2 Name = Secretin family of 7 transmembrane receptors width = caption = Pfam= PF00002 InterPro= IPR000832 SMART= PROSITE = PDOC00559 SCOP = 1bl1 TCDB = OPM family = 6 OPM protein = 1fjr PDB= PDB|1bl1 ; 17 30; PDB|1et2 S 184… …   Wikipedia

  • adrenomedullin — One of the calcitonin family peptides …   Dictionary of molecular biology

  • amylin — Natural hormone produced by pancreatic beta cells that moderates the glucose lowering effects of insulin. One of the calcitonin family peptides …   Dictionary of molecular biology

  • Adrenomedullin — is a peptide associated with pheochromocytoma a tumore arising from adrenal medulla. It was discovered in 1993. [cite journal | author = | title = Quantifying angiogenesis in VEGF enhanced tissue engineered bladder constructs by dynamic contrast… …   Wikipedia

  • CALCRL — Calcitonin receptor like (CALCRL), also known as the calcitonin receptor like receptor (CRLR), is a human gene.cite journal | author = Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y | title = A cDNA encoding the calcitonin… …   Wikipedia

  • endocrine system, human — ▪ anatomy Introduction  group of ductless glands (gland) that regulate body processes by secreting chemical substances called hormones (hormone). Hormones act on nearby tissues or are carried in the bloodstream to act on specific target organs… …   Universalium

  • Insect diuretic hormones — are hormones that regulate water balance through diuretic action.The insect excretory system, responsible for regulating water balance in the insect, comprises the Malpighian tubules and the hindgut (the ileum and rectum). Malpighian tubules… …   Wikipedia

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